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ATP-dependent helicases such as DHX9, the Blooms syndrome helicase (BLM), Aquarius (AQR), FANCM and members of the DExD/H family of RNA helicases or chromatin regulatory factors such as the FACT and SWI/SNF chromatin remodeling complex, INO80 and DAXX/ATRX histone chaperons prevent unprogrammed R-loops 4,10,11,12,13,14

Martello E, Perondi F, Bisanzio D, Lippi I, Meineri G, Gabriele V

Genetics should not replace provider judgment, but it can help inform a more personalized plan

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We need to ensure that reproductive health is part of every conversation when these drugs are prescribed to any women of childbearing age